Ramelteon is used to help patients who have sleep-onset insomnia (difficulty falling asleep) fall asleep more quickly. Ramelteon is in a class of medications called melatonin receptor agonists. It works similarly to melatonin, a natural substance in the brain that is needed for sleep.

What are the adverse of ROZEREM ( Ramelteon )?

Ramelteon has not been shown to produce dependence and has shown no potential for abuse, and the withdrawal and rebound insomnia that is typical with GABA modulators is not present in ramelteon.

Six percent of ramelteon-treated patients in clinical trials discontinued due to an adverse event, compared with two percent in the placebo arms. The most frequent adverse events leading to discontinuation were somnolence, dizziness, nausea, fatigue, headache, and insomnia. The United States official Prescribing Information warns of rare cases of anaphylactic reactions, abnormal thinking, worsening of depression or suicidal thinking in patients with pre-existing depression, and decreased testosterone and increased prolactin levels. It also notes that ramelteon is not recommended for use in patients with severe sleep apnea. Buy ROZEREM ( Ramelteon ) 8mg

In mice treated with ramelteon for two years, increases in liver and testicular tumors were observed, but only at doses at least 20 times greater than the recommended human dose on a milligram/kilogram basis.

Ramelteon may cause side effects. Tell your doctor if either of these symptoms are severe or do not go away:

• drowsiness or tiredness
• dizziness

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

• swelling of the tongue or throat
• difficulty swallowing or; breathing
• feeling that the throat is closing
• nausea
• vomiting
• irregular or missed menstrual periods
• milky discharge from the nipples
• decreased sexual desire
• fertility problems

Ramelteon may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.